Pharmaceutical Desloratadine

Product Description

Desloratadine is a prescription medication used primarily to relieve allergy symptoms Heres an overview of its pharmaceutical profile

Description

Generic Name Desloratadine

Brand Names Commonly marketed under the brand name Clarinex among others

Drug Class Antihistamine secondgeneration

Chemical Formula C19H19ClN2

Molecular Weight 31082 gmol

Appearance Typically comes in the form of tablets orally disintegrating tablets or syrup

Mechanism of Action

Desloratadine is a selective antagonist of peripheral histamine H1 receptors By blocking these receptors it prevents histamine from binding and thereby reduces the allergic symptoms that histamine would normally cause such as itching sneezing and runny nose

Indications

Allergic Rhinitis Relief from symptoms of seasonal and perennial allergic rhinitis such as sneezing runny or itchy nose and itchy or watery eyes

Chronic Urticaria Treatment of chronic idiopathic urticaria hives which includes relief from itching and the appearance of hives

Dosage

Adults and Children Over 12 Years Typically 5 mg once daily

Children Aged 6 to 11 Years Usually 25 mg once daily

Children Aged 1 to 5 Years Dosage often depends on the specific formulation and is typically lower than for older children

Pharmacokinetics

Absorption Desloratadine is wellabsorbed from the gastrointestinal tract with peak plasma concentrations occurring approximately 3 hours after oral administration

Distribution It is widely distributed throughout the body including the central nervous system

Metabolism Metabolized primarily in the liver

Excretion Eliminated through both urine and feces

Side Effects

Common side effects may include

Dry mouth

Fatigue

Headache

Drowsiness although less commonly than with firstgeneration antihistamines

Gastric disturbances such as nausea

Serious side effects are rare but may include severe allergic reactions and should be reported to a healthcare provider if they occur

Precautions

Pregnancy Classified as Category C meaning risk cannot be ruled out should be used only if clearly needed and prescribed by a healthcare provider

Lactation It is unknown whether desloratadine is excreted in breast milk so caution is advised if used during breastfeeding

Renal Impairment Dosage adjustments may be necessary in patients with severe renal impairment

Interactions

Desloratadine generally has fewer drug interactions compared to firstgeneration antihistamines However its advisable to consult a healthcare provider if you are taking other medications especially those affecting liver metabolism or those with sedative effects

Summary

Desloratadine is an effective nonsedating antihistamine used to treat allergic symptoms Its long duration of action and minimal sedative effects make it a preferred choice for many patients needing allergy relief Always use it under the guidance of a healthcare professional to ensure it is appropriate for your condition and situation.

OUR

With the help of our dedicated team of professionals, we have been able to manufacture, supply and export superior quality Desloratadine. This drug is reckoned for high solubility in methanol, chloroform, in dischloromethane and in solubility in water. Our offered drug is widely used to treat allergies. This drug is processed under the strict supervision of our experienced professionals in order to suit the variegated demands of clients. Desloratadine is stringently tested in our laboratory by a team fo quality controllers to ensure high degree of effectiveness.